Combination of bis (α‐furancarboxylato) oxovanadium (IV) and metformin improves hepatic steatosis through down‐regulating inflammatory pathways in high‐fat diet‐induced obese C57BL/6J mice
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منابع مشابه
Metformin ameliorates hepatic steatosis and improves the induction of autophagy in HFD-induced obese mice
The present study aimed to investigate the effect of metformin on the induction of autophagy in the liver and adipose tissues of a mouse model of obesity. C57BL/6J mice were fed a high‑fat diet (HFD) for 12 weeks to induce obesity‑associated hepatic steatosis, and treated with metformin (150 mg/kg/d) by intraperitoneal injection for the final 4 weeks of HFD feeding. Body weight was recorded wee...
متن کاملα-Mangostin Regulates Hepatic Steatosis and Obesity through SirT1-AMPK and PPARγ Pathways in High-Fat Diet-Induced Obese Mice.
Previous studies have shown that α-mangostin (α-MG) suppresses intracellular fat accumulation and stimulation of lipolysis in in vitro systems. Together with the relatively high distribution of α-MG in liver and fat, these observations made it possible to propose a plausible hypothesis that an α-MG supplement may regulate hepatic steatosis and obesity. An α-MG supplement (50 mg/kg) reduced the ...
متن کاملInhibiting glycosphingolipid synthesis ameliorates hepatic steatosis in obese mice.
UNLABELLED Steatosis in the liver is a common feature of obesity and type 2 diabetes and the precursor to the development of nonalcoholic steatohepatitis (NASH), cirrhosis, and liver failure. It has been shown previously that inhibiting glycosphingolipid (GSL) synthesis increases insulin sensitivity and lowers glucose levels in diabetic rodent models. Here we demonstrate that inhibiting GSL syn...
متن کاملShort treatment of metformin attenuated insulin resistance and hepatic steatosis in obese mice by mechanisms independents of PPAR-alpha
Background Nonalcoholic steatohepatitis (NASH) is characterized by accumulation of fat in the liver without excessive alcohol intake [1]. The optimal treatment for this disease is not well established, however, metformin is described as an efficient treatment for NASH and hepatic inflammation [2]. Based on these data, the present study aimed to evaluate the possible immune-metabolic effects of ...
متن کاملHepatic steatosis in obese children and adolescents.
OBJECTIVE To assess the frequency of hepatic steatosis and metabolic syndrome among obese children and adolescents. METHOD A descriptive case series was conducted with 77 patients, aged 2 to 13 years and 11 months, who were followed up from February to July 2007. Obesity was defined as body mass index ≥ P95 adjusted for age and sex. Liver ultrasound was performed to diagnose hepatic steatosis...
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ژورنال
عنوان ژورنال: Basic & Clinical Pharmacology & Toxicology
سال: 2021
ISSN: 1742-7835,1742-7843
DOI: 10.1111/bcpt.13573